JPH0224821B2 - - Google Patents

Info

Publication number
JPH0224821B2
JPH0224821B2 JP56178804A JP17880481A JPH0224821B2 JP H0224821 B2 JPH0224821 B2 JP H0224821B2 JP 56178804 A JP56178804 A JP 56178804A JP 17880481 A JP17880481 A JP 17880481A JP H0224821 B2 JPH0224821 B2 JP H0224821B2
Authority
JP
Japan
Prior art keywords
group
compound
benzimidazole
ethyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP56178804A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5879983A (ja
Inventor
Ryuichi Iemura
Tsuneo Kawashima
Shunichi Fukuda
Keizo Ito
Hisashi Nose
Goro Tsukamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP56178804A priority Critical patent/JPS5879983A/ja
Priority to US06/436,032 priority patent/US4430343A/en
Priority to EP82110215A priority patent/EP0079545B1/en
Priority to AT82110215T priority patent/ATE19878T1/de
Priority to DE8282110215T priority patent/DE3271269D1/de
Publication of JPS5879983A publication Critical patent/JPS5879983A/ja
Publication of JPH0224821B2 publication Critical patent/JPH0224821B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP56178804A 1981-11-06 1981-11-06 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物 Granted JPS5879983A (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP56178804A JPS5879983A (ja) 1981-11-06 1981-11-06 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
US06/436,032 US4430343A (en) 1981-11-06 1982-10-22 Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
EP82110215A EP0079545B1 (en) 1981-11-06 1982-11-05 Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same
AT82110215T ATE19878T1 (de) 1981-11-06 1982-11-05 Benzimidazol-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen.
DE8282110215T DE3271269D1 (en) 1981-11-06 1982-11-05 Benzimidazole derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56178804A JPS5879983A (ja) 1981-11-06 1981-11-06 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物

Publications (2)

Publication Number Publication Date
JPS5879983A JPS5879983A (ja) 1983-05-13
JPH0224821B2 true JPH0224821B2 (en]) 1990-05-30

Family

ID=16054937

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56178804A Granted JPS5879983A (ja) 1981-11-06 1981-11-06 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物

Country Status (5)

Country Link
US (1) US4430343A (en])
EP (1) EP0079545B1 (en])
JP (1) JPS5879983A (en])
AT (1) ATE19878T1 (en])
DE (1) DE3271269D1 (en])

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027973A1 (en) * 1993-05-20 1994-12-08 Kissei Pharmaceutical Co., Ltd. 1-(2-benzimidazolyl)-1,5-diazacyclooctane derivative

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59199679A (ja) * 1983-04-27 1984-11-12 Kanebo Ltd 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
JPS608274A (ja) * 1983-06-27 1985-01-17 Fujisawa Pharmaceut Co Ltd 新規キナゾリノン誘導体およびその製造法・並びに抗アレルギ−剤
JPH0383924A (ja) * 1989-08-28 1991-04-09 Kanebo Ltd 経皮投与用組成物
FR2665161B1 (fr) * 1990-07-26 1992-11-27 Esteve Labor Dr Nouveaux derives de benzimidazole, leur preparation et leur application en tant que medicaments.
FR2668150B1 (fr) * 1990-10-17 1994-11-18 Theramex Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.
ES2038532B1 (es) * 1991-05-10 1994-02-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados de 2-piperacinilbecimidazol.
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
JP3527256B2 (ja) * 1992-12-09 2004-05-17 ロート製薬株式会社 抗アレルギー点眼剤
US5668133A (en) * 1992-12-09 1997-09-16 Alcon Laboratories, Inc. Ophthalmic compositions comprising emedastine and methods for their use
ES2072193B1 (es) * 1993-05-21 1996-02-16 Espanola Prod Quimicos Nuevos derivados del1-fenilmetil bencimidazol piperacinas.
WO1996033722A1 (fr) * 1995-04-27 1996-10-31 Kanebo, Ltd. Preparation externe contenant de l'emedastine
US5676992A (en) 1995-12-13 1997-10-14 Recot, Inc. Process for preventing accumulation of material on a cutting mechanism
WO1997030991A1 (en) * 1996-02-21 1997-08-28 Hoechst Marion Roussel, Inc. Novel substituted n-methyl-n-(4-(4-(1h-benzimidazol-2-yl)[1,4]diazepan-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US20040097486A1 (en) * 1999-11-18 2004-05-20 Yanni John M. Use of an H1 antagonist and a safe steroid to treat eye conditions
TWI225488B (en) * 1999-12-21 2004-12-21 Janssen Pharmaceutica Nv Derivatives of homopiperidinyl substituted benzimidazole analogues
WO2001054687A1 (en) 2000-01-25 2001-08-02 Alcon Universal Ltd. Ophthalmic anti-allergy compositions suitable for use with contact lenses
DK1467762T3 (da) * 2001-12-05 2006-04-10 Alcon Inc Anvendelse af en H1-antagonist og rimexolon som et sikkert steroid til behandling af rhinitis
US20040224917A1 (en) * 2003-01-14 2004-11-11 Gilead Sciences, Inc. Compositions and methods for combination antiviral therapy
US8758816B2 (en) * 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
MX2007006233A (es) 2004-11-24 2007-11-23 Medpointe Healthcare Inc Composiciones que comprenden azelastina y metodos de uso de la misma.
TWI375560B (en) * 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
KR101123903B1 (ko) 2008-02-12 2012-03-23 주식회사유한양행 2-메틸-2'-페닐프로피온산 유도체의 제조 방법 및 이에 사용되는 신규한 중간체 화합물
WO2015115497A1 (ja) 2014-01-31 2015-08-06 久光製薬株式会社 エメダスチン含有テープ剤
JP6488021B2 (ja) * 2015-10-06 2019-03-20 久光製薬株式会社 アクリル系粘着剤の流動化抑制方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2689853A (en) 1954-09-21 Certain i
DE1620450C3 (de) 1964-07-23 1976-01-02 Schering Ag, 1000 Berlin Und 4619 Bergkamen 1 - (2- Hydroxybenzyl) -2-piperazinomethylbenzimidazole, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
JPS50126682A (en]) * 1974-03-25 1975-10-04
US4093726A (en) 1976-12-02 1978-06-06 Abbott Laboratories N-(2-benzimidazolyl)-piperazines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994027973A1 (en) * 1993-05-20 1994-12-08 Kissei Pharmaceutical Co., Ltd. 1-(2-benzimidazolyl)-1,5-diazacyclooctane derivative

Also Published As

Publication number Publication date
EP0079545A1 (en) 1983-05-25
ATE19878T1 (de) 1986-06-15
US4430343A (en) 1984-02-07
EP0079545B1 (en) 1986-05-21
JPS5879983A (ja) 1983-05-13
DE3271269D1 (en) 1986-06-26

Similar Documents

Publication Publication Date Title
JPH0224821B2 (en])
JPH05508660A (ja) ジアリールメチルピペリジンまたはピペラジンのピリジンおよびピリジンｎ−オキシド誘導体、並びにそれらの組成物および使用方法
PT101875B (pt) Derivados de benzeno e processo para a sua preparacao
FR2477542A1 (fr) Derives de carbostyrile, leurs procedes de preparation et leur application en therapeutique
JPH0231078B2 (en])
JPH0440347B2 (en])
JPH0240657B2 (ja) 3*44jihidorokarubosuchirirujudotai
JPS6230780A (ja) １，７−ナフチリジン誘導体及びこれを含有する薬剤
JPH032179A (ja) 精神安定活性を有するピリミジニルピペラジニルアルキルアゾール誘導体
KR850000216B1 (ko) 피페라진 유도체의 제조방법
JPS6259109B2 (en])
JPS6318591B2 (en])
JPH05140108A (ja) ピリジニルピペラジン誘導体
JPH01157979A (ja) １―アシル―３―［４―（２―ピリミジニル）―１―ピペラジニル］プロパン類
JPH08502057A (ja) カルモジュリン拮抗特性を有する複素環式アミン
CZ325196A3 (en) Derivatives of hydroximic acid, pharmaceutical compositions containing thereof, process of their preparation and intermediates used in the preparation process
JPS59199679A (ja) 新規なベンズイミダゾ−ル誘導体、その製造法およびその医薬組成物
JP2726999B2 (ja) イミダゾ［２，１−ｂ］ベンゾチアゾール誘導体及び該化合物を有効成分とする抗潰瘍剤
JPS63145272A (ja) ４，５−ジヒドロ−６−（４−置換フエニル）−３（２ｈ）−ピリダジノン誘導体
JPS6219577A (ja) 新規なベンジルピペラジン誘導体および該化合物を有効成分とする医薬組成物
JPS6344749B2 (en])
DE3132916A1 (de) 1-phenylindazol-3-on-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPH01242574A (ja) 含窒素縮合環を有するピペリジン及びピペラジン誘導体、その製造方法並びにそれを含む薬学的組成物
DE69310186T2 (de) 1,2-dihydro-2-oxo-3-aminochinoxalin derivate, ihre verwendung als heilmittel
JP3092827B2 (ja) アルケンアミド誘導体及びそのアルケンアミド誘導体を用いた抗アレルギー剤、アルケン酸、そのアルケン酸の製造方法

Legal Events

Date Code Title Description
R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term